Ruiz A, Frenkel J K
J Infect Dis. 1976 Apr;133(4):409-18. doi: 10.1093/infdis/133.4.409.
Sarcocystis muris, obtained from laboratory and house mice, was transmitted experimentally to cats. When cysts in the skeletal muscle of mice were ingested by cats, bradyzoites developed directly into gametes in the intestinal mucosa of the cats. After five to 11 days, infectious sporulated sporocysts (8.5 x 10.3 mum) were shed by cats for up to three months. After ingestion of the sporocysts, S. muris multiplied first in the livers and then in the skeletal muscle of mice. Cysts in skeletal muscle attained a length of 5-6 mm and were visible to the naked eye. With heavy infections the cysts outlined major muscle groups. Lesions in mice were apparently the result of degeneration or rupture of cysts, with myositis and sometimes muscle necrosis, leading to locomotor impairment in heavy infection. S. muris required approximately 76 days of development in mice before becoming infectious for cats. S. muris is perpetuated by an obligatory two-host cycle (mouse-cat). Both cats and mice could be infected repeatedly. Rats, hamsters, and guinea pigs did not become infected.
从实验室小鼠和家鼠体内获取的鼠肉孢子虫，通过实验将其传播给猫。当猫摄入小鼠骨骼肌中的包囊时，缓殖子在猫的肠黏膜中直接发育为配子。5至11天后，具感染性的孢子化子孢子囊（8.5×10.3微米）由猫排出，持续长达三个月。摄入子孢子囊后，鼠肉孢子虫先在小鼠肝脏中繁殖，然后在骨骼肌中繁殖。骨骼肌中的包囊长度达到5至6毫米，肉眼可见。重度感染时，包囊勾勒出主要肌群。小鼠的病变显然是包囊退化或破裂的结果，伴有肌炎，有时还有肌肉坏死，导致重度感染时运动功能受损。鼠肉孢子虫在小鼠体内需要约76天的发育时间才能对猫具有感染性。鼠肉孢子虫通过一个必须的双宿主循环（小鼠 - 猫）得以延续。猫和小鼠都可反复感染。大鼠、仓鼠和豚鼠不会被感染。
