Ueno K, Thurumaru H, Furuta S, Ohyama M, Fujimoto T
Department of Otolaryngology, Faculty of Medicine, Kagoshima University.
Nihon Jibiinkoka Gakkai Kaiho. 1994 Mar;97(3):430-5. doi: 10.3950/jibiinkoka.97.430.
Magnetic Resonance Spectroscopy (MRS) has been developed as a new application of nuclear magnetic resonance. By means of MRS, internal chemical information can be non-invasively measured. In this study, the 31P MRS of naso-sinus tumors was measured and evaluated. The peaks of 31P MRS, such as Adenosine tri-phosphate (ATP), Creatine phosphate (PCr), Phosphodiester (PME), Inorganic phosphate (Pi), and Phosphomonoester (PME) can be identified. Phosphomonoesters (PME) are precursors of membrane phospholipids. Phosphodiesters (PDE) are metabolites of phospholipids. Compared with benign tumors, the 31P MRS of malignant tumors shows a higher PME peak and lower PDE and PCr peaks. These results indicate that malignant tumors are characterized by chemical changes in membrane metabolism.
磁共振波谱(MRS)已发展成为核磁共振的一种新应用。借助MRS,可以非侵入性地测量内部化学信息。在本研究中,对鼻窦肿瘤进行了31P MRS测量和评估。可以识别31P MRS的峰,如三磷酸腺苷(ATP)、磷酸肌酸(PCr)、磷酸二酯(PME)、无机磷酸盐(Pi)和磷酸单酯(PME)。磷酸单酯(PME)是膜磷脂的前体。磷酸二酯(PDE)是磷脂的代谢产物。与良性肿瘤相比,恶性肿瘤的31P MRS显示出较高的PME峰和较低的PDE及PCr峰。这些结果表明,恶性肿瘤的特征是膜代谢的化学变化。