Kudo M, Mizuno Y, Morita H, Miyazaki M
Department of Neurology, Tokyo Metropolitan Ebara Hospital.
Nihon Rinsho. 1997 Jan;55(1):255-61.
We report 31P magnetic resonance spectroscopy(MRS) to study regional high energy phosphate and phospholipid metabolism in basal ganglia of patients with Parkinson's disease(PD) in comparison with normal controls. The ratio of phosphomonoester(PME)/phosphocreatine(PCr), phosphodiester(PDE)/PCr and total Adenosine triphosphate(ATP) tend to decrease and the ratio of PDE/PME tend to elevate compared with controls. Moreover these findings are correlated with the duration of illness. Our results suggest that neural elements in basal ganglia may be damaged in PD. In conclusion, 31P-MRS appears to be useful for the study of neural damage and degeneration in vivo.
我们报告采用31P磁共振波谱（MRS）来研究帕金森病（PD）患者基底神经节区域的高能磷酸和磷脂代谢，并与正常对照组进行比较。与对照组相比，磷酸单酯（PME）/磷酸肌酸（PCr）、磷酸二酯（PDE）/PCr以及总三磷酸腺苷（ATP）的比值呈下降趋势，而PDE/PME的比值呈上升趋势。此外，这些发现与病程相关。我们的结果表明，PD患者基底神经节中的神经元可能受损。总之，31P-MRS似乎有助于体内神经损伤和退变的研究。
