Fernie S, Wrenshall E, Malcolm S, Bryce F, Arnold D L
Toxicology Research Division, Health and Welfare Canada, Ontario.
J Toxicol Environ Health. 1994 May;42(1):53-72. doi: 10.1080/15287399409531863.
During the conduct of a long-term toxicity/reproduction study using rhesus monkeys (Macaca mulatta), periodic hematologic and serum biochemical analyses were undertaken on blood obtained from 15 untreated (vehicle control) adult female monkeys over a period of 3 yr, 20 untreated adult males over a period of 6 yr, and 9 infants (5 male, 4 female, whose dams were the vehicle control females) from 12 wk through 2 yr of age. All samples were obtained by femoral puncture. To facilitate handling, ketamine hydrochloride (Ket.HCl) was administered to the males, and for some of the later infant samplings. Complete blood cell counts were performed using electronic cell counters, while reticulocyte counts and leukocyte differentials were assessed manually. The serum biochemistry analyses were performed with automated analyzers. These data were obtained as part of a health monitoring program, with medians and 2.5 to 97.5 percentiles for each parameter indicated. Some monitored parameters were found to be affected by the type of equipment used and by the use of Ket.HCl.
在一项使用恒河猴（猕猴）进行的长期毒性/生殖研究中，对15只未接受处理（溶媒对照）的成年雌性猴子在3年期间、20只未接受处理的成年雄性猴子在6年期间以及9只婴儿猴（5只雄性，4只雌性，其母猴为溶媒对照雌性猴子）从12周龄至2岁期间采集的血液进行了定期血液学和血清生化分析。所有样本均通过股静脉穿刺采集。为便于操作，对雄性猴子以及部分后期婴儿猴采样时给予了盐酸氯胺酮（Ket.HCl）。使用电子细胞计数器进行全血细胞计数，而网织红细胞计数和白细胞分类则通过手工评估。血清生化分析使用自动分析仪进行。这些数据是作为健康监测计划的一部分获得的，每个参数均列出了中位数以及第2.5至97.5百分位数。发现一些监测参数受所用设备类型以及盐酸氯胺酮使用的影响。
