恒河猴（猕猴）妊娠头三个月血液参数的变化。
Changes in blood parameters in rhesus monkeys (Macaca mulatta) during the first trimester of gestation.
作者信息
Ibáñez-Contreras Alejandra, Hernández-Godínez Braulio, Reyes-Pantoja Sergio A, Jiménez-García Andrea, Solís-Chavéz Salvador A, Suarez-Gutiérrez Rodrigo, Gálvan-Montaño Alfonso
机构信息
Centro de Investigación, Proyecto CAMINA, A.C., Ciudad de México, México D.F, México.
出版信息
J Med Primatol. 2013 Aug;42(4):171-6. doi: 10.1111/jmp.12052. Epub 2013 Apr 26.
BACKGROUND
Regarding the good practice in the laboratory work, it is essential to have a broad spectrum of biochemical and hematological references in pregnant females to determine the health status of the colony.
OBJECTIVE
To establish reference values to reveal changes in hematology and blood chemistry in pregnant rhesus monkeys (Macaca mulatta) in their first trimester of pregnancy.
METHODS
Twenty-eight females in reproductive stage were used, divided into two groups: 14 pregnant macaques in their first trimester and 14 non-pregnant used as the control group. Blood samples were collected for the hematological test and blood chemistry.
RESULTS
The results showed significant difference in the blood chemistry for the following parameters: glucose, total bilirubin, and total protein. The hematological evaluation revealed significant difference in leukocytes and neutrophils.
CONCLUSIONS
These findings offer a reference range and provide a basis for improvement in techniques and refinement of clinical processes in these specimens.
背景
关于实验室工作的良好规范，掌握怀孕雌性动物广泛的生化和血液学参考值对于确定群体的健康状况至关重要。
目的
建立参考值以揭示怀孕恒河猴（猕猴）妊娠早期血液学和血液化学的变化。
方法
使用28只处于生殖期的雌性恒河猴，分为两组：14只妊娠早期的怀孕猕猴和14只未怀孕的作为对照组。采集血样进行血液学检测和血液化学分析。
结果
结果显示以下参数在血液化学方面存在显著差异：葡萄糖、总胆红素和总蛋白。血液学评估显示白细胞和中性粒细胞存在显著差异。
结论
这些发现提供了一个参考范围，并为改进这些样本的技术和完善临床流程提供了依据。
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