Rutherford C J, Frenkel E P
Division of Hematology-Oncology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas.
Med Clin North Am. 1994 May;78(3):555-75. doi: 10.1016/s0025-7125(16)30147-x.
Thrombocytopenia is defined by clinical characteristics and pathophysiologic mechanisms. The patient with thrombocytopenia often presents diagnostic and management challenges simultaneously. The differential diagnosis is broad because the disorders leading to thrombocytopenia are diverse, with failed production at one extreme and accelerated destruction at the other. Reviewed in terms of diagnosis and therapy are pseudothrombocytopenia, dilutional thrombocytopenia, and the three major mechanisms: decreased production, altered distribution, and increased destruction.
血小板减少症是由临床特征和病理生理机制所定义的。血小板减少症患者常常同时面临诊断和管理方面的挑战。鉴别诊断范围广泛，因为导致血小板减少症的病症多种多样，一端是生成失败，另一端是破坏加速。本文从诊断和治疗方面对假性血小板减少症、稀释性血小板减少症以及三种主要机制（生成减少、分布改变和破坏增加）进行了综述。
