大鼠脑中的成纤维细胞生长因子受体4（FGF receptor-4）信使核糖核酸（mRNA）优先在内侧缰核中表达。
Rat FGF receptor-4 mRNA in the brain is expressed preferentially in the medial habenular nucleus.
作者信息
Itoh N, Yazaki N, Tagashira S, Miyake A, Ozaki K, Minami M, Satoh M, Ohta M, Kawasaki T
机构信息
Department of Genetic Biochemistry, Kyoto University Faculty of Pharmaceutical Sciences, Japan.
出版信息
Brain Res Mol Brain Res. 1994 Feb;21(3-4):344-8. doi: 10.1016/0169-328x(94)90265-8.
The fibroblast growth factor (FGF) receptor family consists of four members, FGFR-1, FGFR-2, FGFR-3 and FGFR-4, that are closely related receptor tyrosine kinases. We examined the expression of rat FGFR-4 mRNA in the brain by in situ hybridization and compared it with that of the mRNAs for other FGF receptors. In contrast with FGFR-1, FGFR-2 and FGFR-3 mRNAs which are expressed widely in the brain, the FGFR-4 mRNA in the brain is expressed preferentially in the medial habenular nucleus neurons. The present finding indicates that FGFR-4 has a function specific to the medial habenular nucleus.
成纤维细胞生长因子（FGF）受体家族由四个成员组成，即FGFR - 1、FGFR - 2、FGFR - 3和FGFR - 4，它们是密切相关的受体酪氨酸激酶。我们通过原位杂交检测了大鼠FGFR - 4 mRNA在脑中的表达，并将其与其他FGF受体的mRNA表达进行了比较。与在脑中广泛表达的FGFR - 1、FGFR - 2和FGFR - 3 mRNA不同，脑中的FGFR - 4 mRNA优先在内侧缰核神经元中表达。目前的发现表明FGFR - 4具有内侧缰核特有的功能。
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