出生后发育期间大鼠小脑内成纤维细胞生长因子受体-4信使核糖核酸的瞬时表达。
Transient expression of FGF receptor-4 mRNA in the rat cerebellum during postnatal development.
作者信息
Miyake A, Minami M, Satoh M, Ohta M, Itoh N
机构信息
Department of Genetic Biochemistry, Kyoto University Faculty of Pharmaceutical Sciences, Japan.
出版信息
Brain Res Mol Brain Res. 1995 Jul;31(1-2):95-100. doi: 10.1016/0169-328x(95)00039-u.
The fibroblast growth factor (FGF) receptor-4 mRNA in the adult rat brain is expressed preferentially in the medial habenular nucleus. In this paper, we examined the expression of FGFR-4 mRNA in the brain during postnatal development. Interestingly, in addition to the persistent expression of FGFR-4 mRNA in the medial habenular nucleus, FGFR-4 mRNA was transiently expressed in the proliferative zone of the external granule layer of the developing cerebellum. The localization and transient expression of FGFR-4 mRNA in the developing cerebellum suggest that FGFR-4 mRNA was expressed by proliferative granule cells. The present findings indicate that FGFR-4 in the brain has an important role in the postnatal development of the cerebellar cortex.
成体大鼠脑中的成纤维细胞生长因子（FGF）受体-4 mRNA 优先在内侧缰核中表达。在本文中，我们研究了出生后发育过程中脑内 FGFR-4 mRNA 的表达情况。有趣的是，除了内侧缰核中 FGFR-4 mRNA 的持续表达外，FGFR-4 mRNA 在发育中小脑外颗粒层的增殖区短暂表达。FGFR-4 mRNA 在发育中小脑中的定位和短暂表达表明它是由增殖的颗粒细胞表达的。目前的研究结果表明，脑中的 FGFR-4 在小脑皮质的出生后发育中起重要作用。
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