Wang S J, Liao K K, Liou H H, Lee S S, Tsai C P, Lin K P, Kao K P, Wu Z A
Neurological Institute, Veterans General Hospital-Taipei, Taiwan, ROC.
Muscle Nerve. 1994 Apr;17(4):411-8. doi: 10.1002/mus.880170408.
Sympathetic skin response (SSR) and R-R interval variation (RRIV) were studied in 36 chronic, nondiabetic uremics to compare with their nerve conduction studies (NCS) and clinical dysautonomia. Abnormal SSR was noted in 5 (13.9%) patients, abnormal RRIV in 14 (38.9%), and abnormal NCS in 26 (72.2%). The patients were classified into three groups: group (GP) 1: "normal," n = 21 (58.3%), normal RRIV and SSR; GP 2: "isolated parasympathetic dysfunction," n = 10 (27.8%), abnormal RRIV and normal SSR; and GP 3: "sympathetic sudomotor dysfunction," n = 5 (13.9%), abnormal SSR. A significant difference in age was found among the three groups (GP 3 > GP 2 > GP 1; P < 0.0001, ANOVA). After controlling the age factor, we still noted a tendency toward increasing NCS disturbances (distal latency and nerve conduction velocity of peroneal nerve; P < 0.05, multiple regression analysis) and frequencies of clinical autonomic symptoms (postural dizziness and impotence; P < 0.05, Mantel-Hanszel test) from GP 1 to GP 3. Patients with abnormal SSR (GP 3) displayed significantly higher frequencies of postural dizziness and impotence, indicating the relationship between an absence of SSR and clinical dysautonomia.
对36例慢性非糖尿病尿毒症患者进行了交感皮肤反应（SSR）和R-R间期变异（RRIV）研究，以与他们的神经传导研究（NCS）和临床自主神经功能障碍进行比较。5例（13.9%）患者SSR异常，14例（38.9%）RRIV异常，26例（72.2%）NCS异常。患者被分为三组：第1组（GP1）：“正常”，n = 21（58.3%），RRIV和SSR正常；第2组（GP2）：“孤立性副交感神经功能障碍”，n = 10（27.8%），RRIV异常而SSR正常；第3组（GP3）：“交感汗腺运动功能障碍”，n = 5（13.9%），SSR异常。三组之间年龄存在显著差异（GP3 > GP2 > GP1；P < 0.0001，方差分析）。在控制年龄因素后，我们仍然注意到从GP1到GP3，NCS异常（腓总神经的远端潜伏期和神经传导速度；P < 0.05，多元回归分析）以及临床自主神经症状（体位性头晕和阳痿；P < 0.05，Mantel-Hanszel检验）的频率有增加的趋势。SSR异常（GP3）的患者体位性头晕和阳痿的频率显著更高，表明SSR缺失与临床自主神经功能障碍之间的关系。
