Maness L M, Kastin A J, Weber J T, Banks W A, Beckman B S, Zadina J E
Tulane University School of Medicine, New Orleans, LA 70146.
Neurosci Biobehav Rev. 1994 Spring;18(1):143-59. doi: 10.1016/0149-7634(94)90043-4.
The neurotrophins are a family of polypeptides that promote differentiation and survival of select peripheral and central neurons. Nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, neurotrophin-4, and neurotrophin-5 are included in this group. In recent years, tremendous advances have been made in the study of these factors. This has stimulated our review of the field, characterizing the neurotrophins from initial isolation to molecular analysis. The review also discusses their synthesis, localization, and responsive tissues, in both the periphery and CNS. The complex receptor interactions of the neurotrophins are also analyzed, as are putative signal transduction mechanisms. Discussion of the observed and postulated involvement in neuropathological disorders leads to the conclusion that the neurotrophins are involved in the function and dysfunction of the nervous system.
神经营养因子是一类多肽家族，可促进特定外周和中枢神经元的分化与存活。该家族包括神经生长因子、脑源性神经营养因子、神经营养因子-3、神经营养因子-4和神经营养因子-5。近年来，这些因子的研究取得了巨大进展。这促使我们对该领域进行综述，描述从最初分离到分子分析的神经营养因子。综述还讨论了它们在外周和中枢神经系统中的合成、定位及反应组织。同时也分析了神经营养因子复杂的受体相互作用以及假定的信号转导机制。对神经营养因子在神经病理疾病中已观察到的和推测的作用的讨论得出结论：神经营养因子与神经系统的功能及功能障碍有关。
