Eide F F, Lowenstein D H, Reichardt L F
Department of Neurology, University of California, San Francisco 94143-0724.
Exp Neurol. 1993 Jun;121(2):200-14. doi: 10.1006/exnr.1993.1087.
Nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 are members of a family of proteins (the neurotrophins) that promote the differentiation, growth, and survival of peripheral and central nervous system neurons. Recently, the trk family of proto-oncogenes has been found to encode signal-transducing receptors for these growth factors. This discovery has important implications for our understanding of the normal function of these factors in the developing and adult nervous system. In this review, we highlight recent advances in neurotrophin research and discuss their relevance to neurologic disease.
神经生长因子、脑源性神经营养因子、神经营养素-3和神经营养素-4/5是一族蛋白质（神经营养因子）的成员，这些蛋白质可促进外周和中枢神经系统神经元的分化、生长及存活。最近，已发现原癌基因trk家族编码这些生长因子的信号转导受体。这一发现对于我们理解这些因子在发育中和成年神经系统中的正常功能具有重要意义。在本综述中，我们着重介绍神经营养因子研究的最新进展，并讨论它们与神经疾病的相关性。
