Daniele E, Nuara R, Morello V, Nagar C, Tralongo V, Tomasino R M
Cattedra di Anatomia ed Istologia Patologica R, Università di Palermo.
Pathologica. 1993 Nov-Dec;85(1100):607-35.
Microglandular hyperplasia is a lesion of the uterine endocervical mucosa, often associated with a story of contraceptive drugs or pregnancy. It was frequently confused with adenocarcinoma or premalignant glandular changes until its benign nature was recognized. In order to ascertain clinical presentation, hormonal or gestational status, histologic patterns with their variants and cytologic counter-part, we collected and reviewed 28 cases of this condition over a period of a decade. The age ranged from 23 to 54, with a mean of 37.2 years. 11 patients had been receiving oral contraceptives and 5 were pregnant. All samples came from uterine cervix. Cervical smears were available from 17 women. Four histologic patterns were identified, including glandular, reticular, trabecular and solid. Cytologic features varied from aspecific, inflammatory changes of the columnar endocervical cells to more particular findings, including clear cells, strips, sheets, papillae, rosettes and corolla-like aggregates. Moreover, differential diagnostic criteria from cervical neoplasms and various pseudoneoplastic conditions of the cervical glandular epithelium are discussed. An extensive review of the literature is also presented.
微腺型增生是子宫颈内膜黏膜的一种病变，常与服用避孕药或妊娠史有关。在其良性本质被认识之前，它常被误诊为腺癌或癌前腺性改变。为了确定其临床表现、激素或妊娠状态、组织学模式及其变体以及细胞学对应表现，我们在十年间收集并回顾了28例该疾病病例。患者年龄在23岁至54岁之间，平均年龄为37.2岁。11例患者一直在服用口服避孕药，5例患者处于妊娠期。所有样本均取自子宫颈。17名女性有宫颈涂片。识别出四种组织学模式，包括腺型、网状、小梁状和实性。细胞学特征从柱状宫颈内膜细胞的非特异性炎症改变到更特殊的表现不等，包括透明细胞、条带、片状、乳头、玫瑰花结和花冠样聚集物。此外，还讨论了与宫颈肿瘤和宫颈腺上皮各种假肿瘤性病变的鉴别诊断标准。同时还对相关文献进行了广泛综述。
