[围产期结节性肝硬化大鼠快速进展性胆汁性肝硬化诱导的实验模型]
[Experimental model of induction in the rat of rapidly developing biliary cirrhosis in peripartal nodular cirrhosis].
作者信息
Novelli A, Gambella G R, Anselmo E, Nanni G
机构信息
Istituto di Patologia generale, Università degli Studi di Genova.
出版信息
Pathologica. 1993 Nov-Dec;85(1100):713-20.
PMID:8170719
Abstract
The treatment with CCl4 and progesterone subsequent the common biliary duct ligature induced, in the rat, after 4-5 weeks, a cirrhotic picture characterized by an early and strong biliary epithelium proliferation followed by a perilobular fibrosis with a concentric sclerosis as in true perilobular cirrhosis.
摘要
在胆总管结扎后用四氯化碳和孕酮处理大鼠，4至5周后会诱发肝硬化病变，其特征为早期且强烈的胆管上皮细胞增殖，随后出现小叶周围纤维化并伴有同心性硬化，如同真正的小叶周围肝硬化。
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