Izquierdo N J, Traboulsi E I, Enger C, Maumenee I H
Johns Hopkins Center for Hereditary Eye Diseases, Wilmer Ophthalmological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Am J Ophthalmol. 1994 May 15;117(5):632-5. doi: 10.1016/s0002-9394(14)70069-8.
We studied 573 patients with the Marfan syndrome for the presence of ocular misalignment, refractive errors, and amblyopia. A total of 110 patients (19.2%) had strabismus. Of 573 patients, exotropia occurred in 67 (11.7%), esotropia in 12 (2.1%), vertical deviations in eight (1.4%), and primary inferior oblique muscle overaction in three (0.5%). Of 67 patients with exotropia, 18 had anisometropia and 39 had amblyopia. Of the 12 patients with esotropia, four had amblyopia and none had anisometropia. Exotropia and esotropia are more common in patients with the Marfan syndrome than in the general population of the United States (P < .001 for exotropia and .05 < P < .10 for esotropia). Abnormal afferent visual inputs to cortical centers caused by ectopia lentis, craniofacial abnormalities, and mechanical and genetic factors may all contribute to the higher prevalence of strabismus in this disease.
我们研究了573例马方综合征患者，以确定是否存在眼球斜视、屈光不正和弱视。共有110例患者（19.2%）患有斜视。在573例患者中，外斜视67例（11.7%），内斜视12例（2.1%），垂直斜视8例（1.4%），原发性下斜肌亢进3例（0.5%）。在67例外斜视患者中，18例有屈光参差，39例有弱视。在12例内斜视患者中，4例有弱视，无屈光参差患者。马方综合征患者中外斜视和内斜视比美国普通人群更常见（外斜视P <.001，内斜视0.05 < P <.10）。晶状体异位、颅面异常以及机械和遗传因素导致的传入视皮质中枢的视觉输入异常，可能都导致了该病斜视患病率较高。
