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条件性趋近:条件性回避的类似物;氯丙嗪和地西泮的作用

Conditioned approach: an analogue of conditioned avoidance; effects of chlorpromazine and diazepam.

作者信息

Migler B

出版信息

Pharmacol Biochem Behav. 1975 Nov-Dec;3(6):961-5. doi: 10.1016/0091-3057(75)90002-7.

Abstract

An analogue of the conditioned avoidance test, the conditioned approach test, was designed in which the reinforcing event was eating food rather than avoiding or escaping shock. A response to the approach stimulus resulted in immediate delivery of food. Failure to respond to the approach stimulus for 15 sec resulted in the delivery of a food pellet. Administration of chlorpormazine at 2--4 mg/kg, PO to squirrel monkeys resulted in the failure of the monkeys to respond to many approach stimuli although they promptly responded to the freely delivered food pellet. Diazepam was without effect at doses up to 100 mg/kg, PO.

摘要

设计了一种条件性回避试验的类似试验——条件性趋近试验,其中强化事件是进食而非躲避或逃避电击。对趋近刺激的反应会导致立即给予食物。若未能对趋近刺激做出反应达15秒,则会给予一粒食物颗粒。给松鼠猴口服2至4毫克/千克的氯丙嗪后,尽管它们能迅速对自由给予的食物颗粒做出反应,但却无法对许多趋近刺激做出反应。口服剂量高达100毫克/千克的地西泮则没有效果。

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