Stolar N, Berenbaum H, Banich M T, Barch D
University of Illinois at Urbana-Champaign.
Biol Psychiatry. 1994 Feb 1;35(3):164-72. doi: 10.1016/0006-3223(94)91148-7.
We examined whether two negative symptoms, alogia and affective flattening, were more strongly associated with dysfunction of certain brain regions than with others in a sample of 27 schizophrenic subjects. Neuropsychological tests were used to measure the integrity of functioning of different brain regions. Functioning of left and right frontal regions was assessed by word fluency and design fluency, respectively, and functioning of the left temporo-hippocampal region was assessed by Hebb's digit-sequences recall test. Measures of alogia and affective flattening were obtained using the Scale for the Assessment of Negative Symptoms. The results indicated that more severe levels of these negative symptoms were associated with poorer performance on the fluency tests. These relationships were fairly specific as indicated in two ways: (1) only certain neuropsychological measures were associated with negative symptoms; and (2) poor performance on fluency tests was not associated with all psychiatric symptoms. In addition, affective flattening, but not alogia, appeared to be associated with lateralized dysfunction.
我们在27名精神分裂症患者样本中研究了两种阴性症状，即言语贫乏和情感平淡，与某些脑区功能障碍的关联是否比与其他脑区的关联更强。神经心理学测试用于测量不同脑区功能的完整性。分别通过词语流畅性和图形流畅性评估左右额叶区域的功能，通过赫布数字序列回忆测试评估左颞叶-海马区的功能。使用阴性症状评估量表获得言语贫乏和情感平淡的测量值。结果表明，这些阴性症状的更严重程度与流畅性测试中的较差表现相关。这些关系相当具有特异性，体现在两个方面：（1）只有某些神经心理学测量与阴性症状相关；（2）流畅性测试中的较差表现与所有精神症状均无关联。此外，情感平淡似乎与单侧性功能障碍有关，而言语贫乏则不然。
