Blanchard J J, Kring A M, Neale J M
Dept. of Psychiatry, Medical College of Pennsylvania/EPPT, Philadelphia 19129.
Schizophr Bull. 1994;20(2):311-25. doi: 10.1093/schbul/20.2.311.
This study evaluated the association between neuropsychological indices of frontal lobe and right hemisphere impairment and deficits in the expression of affect in schizophrenia. The advantages of the present study were that unmedicated schizophrenia patients were studied and relevant demographic characteristics were controlled. Furthermore, deficits in affective expression were assessed both in a clinical interview and in subjects' response to affect-eliciting films. Despite the fact that schizophrenia subjects demonstrated significantly higher clinical ratings of affective flattening and less facial expression while viewing films than demographically matched control subjects, neuropsychological performance was not consistently related to these expressive deficits. The results thus failed to support for the proposed neuropsychological models of affective deficits in schizophrenia. The characterization of flat affect as a purely emotional deficit is questioned, and limitations of current neuropsychological theories of emotional expression and neuropsychological methods to test these theories in the study of schizophrenia are discussed as relevant concerns for future research.
本研究评估了额叶和右半球损伤的神经心理学指标与精神分裂症情感表达缺陷之间的关联。本研究的优势在于对未服药的精神分裂症患者进行了研究，并控制了相关人口统计学特征。此外，在临床访谈以及受试者对引发情感的影片的反应中，均对情感表达缺陷进行了评估。尽管精神分裂症患者在观看影片时表现出明显更高的情感平淡临床评分且面部表情较少，但与人口统计学匹配的对照组相比，神经心理学表现与这些表达缺陷并无一致关联。因此，研究结果未能支持所提出的精神分裂症情感缺陷神经心理学模型。情感平淡作为一种纯粹的情感缺陷的特征受到质疑，并且在精神分裂症研究中，当前情感表达神经心理学理论的局限性以及用于检验这些理论的神经心理学方法，作为未来研究的相关关注点进行了讨论。
