Mo R, Omvik P, Lund-Johansen P, Myking O L
Department for Heart Diseases, University of Bergen, School of Medicine, Haukeland Hospital, Norway.
Blood Press. 1993 Dec;2(4):278-83. doi: 10.3109/08037059309077168.
Sodium intake, estimated by the 24-h urine sodium excretion, was assessed in 39 offspring of hypertensive families and 37 offspring of normotensive families. The family history of hypertension or normotension was defined according to parental BP data from two surveys conducted 27 years apart. Urine-sodium excretion was similar in offspring of hypertensive and normotensive families, averaging 136 and 137 mmol/24 h, respectively. Monitored by non-invasive methodology in the urine sampling period, the average 24-h ambulatory blood pressure (BP) was approximately 10/10 mmHg higher in offspring of hypertensive than normotensive families. The clinically and statistically significant differences in BP between groups could not be explained by differences in sodium intake. After adjustment for confounding variables, the BP was not associated with the sodium excretion in the material as a whole or in either offspring group.
通过24小时尿钠排泄量估算的钠摄入量，在39名高血压家族的后代和37名血压正常家族的后代中进行了评估。高血压或血压正常的家族史是根据相隔27年进行的两项调查中父母的血压数据来定义的。高血压家族和血压正常家族的后代尿钠排泄量相似，平均分别为136和137 mmol/24小时。在尿液采样期间通过非侵入性方法监测，高血压家族的后代24小时动态血压平均比血压正常家族的后代高约10/10 mmHg。两组之间血压在临床和统计学上的显著差异无法用钠摄入量的差异来解释。在对混杂变量进行调整后，整体材料或任何一组后代中，血压与钠排泄均无关联。
