Mo R, Lund-Johansen P, Omvik P
Department for Heart Diseases, University of Bergen, School of Medicine, Haukeland Hospital, Norway.
Blood Press. 1993 Sep;2(3):197-204. doi: 10.3109/08037059309077551.
24-hour ambulatory blood pressure (BP) was monitored by non-invasive methods in 42 offspring of hypertensive families (age [mean (SD1)] 40(7) years) and 38 offspring of normotensive families (age 33(6) years). The family history was defined according to parental BP data from two surveys conducted 27 years apart. Casual BP was 137(17)/84(12) mmHg in offspring of hypertensive families and 117(9)/69(6) mmHg in offspring of normotensive families (difference: p < 0.001). Average 24-h BP was 123(10)/74(6) mmHg and 113(8)/65(5) mmHg, respectively (difference: p < 0.001). The systolic and diastolic BP difference of approximately 10 mmHg was observed between the groups throughout the monitoring period. Hypertension--defined according to a recent meta-analysis as an average 24-h BP > or = 139/87 mmHg--was found in 6 offspring of hypertensive families and in no offspring of normotensive families (p < 0.05). The 24-h systolic and diastolic BP load--the percentage of readings above 140/90 mmHg (day-time) and 120/80 mmHg (night-time)--was higher in offspring of hypertensive than normotensive families (27%/17% vs. 7%4%; p < 0.001). After adjustment for intrafamilial covariation, age, and other possibly confounding variables, the differences between the groups remained. The present findings suggest that BP in subjects with a family history of hypertension is elevated on a permanent basis, and not only when it is measured in the doctor's office.
采用无创方法对42名高血压家族后代（年龄[平均（标准差）]40（7）岁）和38名血压正常家族后代（年龄33（6）岁）进行了24小时动态血压监测。家族病史根据相隔27年进行的两项调查中的父母血压数据来确定。高血压家族后代的偶测血压为137（17）/84（12）mmHg，血压正常家族后代的偶测血压为117（9）/69（6）mmHg（差异：p<0.001）。24小时平均血压分别为123（10）/74（6）mmHg和113（8）/65（5）mmHg（差异：p<0.001）。在整个监测期间，两组之间的收缩压和舒张压差异约为10mmHg。根据最近的一项荟萃分析，高血压定义为24小时平均血压≥139/87mmHg，在6名高血压家族后代中发现高血压，而血压正常家族后代中未发现（p<0.05）。高血压家族后代的24小时收缩压和舒张压负荷（高于140/90mmHg（白天）和120/80mmHg（夜间）读数的百分比）高于血压正常家族后代（27%/17%对7%/4%；p<0.001）。在对家族内协变量、年龄和其他可能的混杂变量进行校正后，两组之间的差异仍然存在。目前的研究结果表明，有高血压家族史的受试者血压持续升高，而不仅仅是在医生办公室测量时升高。
