Bloom F E
Psychopharmacol Commun. 1975;1(6):579-85.
The emergence of specific concepts of possible neuronal pathophysiology in mental disorders has recently been accelerated by the realization that the central catecholamine and indoleamine pathways show potent and widespread actions in animal experiments. These functional properties have been characterized in part by new methods of neuronal circuit analysis, more specific methods of neuronal cytochemistry, and by extensive exploitation of more classical electrophysiological methodologies for the assessment of synaptic transmitter identification and mechanism, the results of experiments at the cellular level have permitted additional studies to be done on the possible behavioral significance of the events regulated by monamines in the awake animal, When the cytochemical and electrophysiological and behavioral exeriments are considered as connected aspects of the same brain sub-systems, then the simple electrophysiological concepts of excitation and inhibition seem inadequate to explain the integrative, amplifying and biochemical actions which can be performed by experimental manipulation of central monamine pathways.
最近，由于认识到中枢儿茶酚胺和吲哚胺途径在动物实验中显示出强大而广泛的作用，精神障碍中可能的神经元病理生理学特定概念的出现加速了。这些功能特性部分已通过神经元回路分析的新方法、更特异的神经元细胞化学方法以及对更经典的电生理方法的广泛应用来评估突触递质识别和机制得以表征。细胞水平实验的结果使得在清醒动物中对单胺调节的事件的可能行为意义进行更多研究成为可能。当将细胞化学、电生理和行为实验视为同一脑亚系统的相关方面时，那么简单的兴奋和抑制电生理概念似乎不足以解释通过对中枢单胺途径进行实验操作所能产生的整合、放大和生化作用。
