Matsuda A, Kimura M, Takeda T, Kataoka M, Sato M, Itokawa Y
Research Laboratories, Roussel Morishita Co., Ltd., Shiga, Japan.
Clin Chem. 1994 May;40(5):829-32.
We measured the manganese content of mononuclear blood cells and the manganese concentrations in whole blood and plasma from 31 healthy volunteers and 25 patients receiving total parenteral nutrition (TPN) (i.e., no dietary manganese). The manganese content (mean +/- 2 SD) of mononuclear blood cells and the manganese concentration in whole blood and plasma in the healthy volunteers were 8.84 +/- 4.18 ng/10(8) cells, 11.21 +/- 4.68 micrograms/L, and 1.21 +/- 0.72 micrograms/L, respectively. The manganese content of mononuclear blood cells from patients receiving TPN gradually decreased, falling below the lowest limit of the normal range by 21 weeks (95% confidence limits, 13-30 weeks) after starting TPN. Manganese concentrations in whole blood and plasma were within normal limits during our study period. These results suggest that the manganese content of mononuclear blood cells may better indicate manganese nutritional status than whole-blood or plasma concentrations.
我们测量了31名健康志愿者以及25名接受全胃肠外营养（TPN）（即无膳食锰摄入）患者的单核血细胞锰含量、全血和血浆中的锰浓度。健康志愿者单核血细胞的锰含量（均值±2标准差）、全血和血浆中的锰浓度分别为8.84±4.18纳克/10⁸个细胞、11.21±4.68微克/升和1.21±0.72微克/升。接受TPN治疗的患者单核血细胞的锰含量逐渐下降，在开始TPN治疗后21周（95%置信区间，13 - 30周）降至正常范围下限以下。在我们的研究期间，全血和血浆中的锰浓度均在正常范围内。这些结果表明，与全血或血浆浓度相比，单核血细胞的锰含量可能更能准确反映锰的营养状况。
