Wang W L
Department of Pathology, Fourth Military Medical University, Xi'an.
Zhonghua Zhong Liu Za Zhi. 1993 Jul;15(4):252-5.
Surgical specimens of 20 cases of human intrahepatic cholangiocarcinoma (n = 12) and cholangiohepatocarcinoma (n = 8) were studied immunohistochemically by ABC technique for HBxAg, pre-S1 and pre-S2 and by PAP method for HBsAg and HBcAg. The neighboring liver tissues with chronic hepatitis or cirrhosis surrounding the tumor were also examined in 19 cases. Of the cancerous tissues, 15 were positive for HBxAg (75%), 8 positive for pre-S1 and pre-S2 (40%), respectively and 2 for HBsAg (10%). Sixteen of 19 liver tissues surrounding the tumor were also positive for HBxAg (84.2%), 9 for pre-S1 and pre-S2 each (47.4%), 6 for HBsAg and HBcAg each (31.6%). The results suggest that a close relationship exists between cholangiocarcinoma and cholangiohepatocarcinoma and hepatitis B virus infection. The HBxAg might play an important role in the pathogenesis of cholangiocarcinoma.
应用ABC技术对20例人肝内胆管癌（12例）和肝门胆管癌（8例）手术标本进行HBxAg、前S1和前S2免疫组化研究，应用PAP法对HBsAg和HBcAg进行免疫组化研究。对其中19例肿瘤周围伴有慢性肝炎或肝硬化的肝组织也进行了检测。癌组织中，15例HBxAg阳性（75%），8例前S1和前S2分别阳性（40%），2例HBsAg阳性（10%）。19例肿瘤周围肝组织中，16例HBxAg阳性（84.2%），9例前S1和前S2分别阳性（47.4%），6例HBsAg和HBcAg分别阳性（31.6%）。结果提示胆管癌、肝门胆管癌与乙型肝炎病毒感染之间存在密切关系。HBxAg可能在胆管癌发病机制中起重要作用。
