Liu Xiao-Fang, Zou Sheng-Quan, Qiu Fa-Zu
Department of Hepatobiliary Surgery of Affiliated Yantai Yuhuangding Hospital, Qingdao University Medical College, Yantai 264000, China.
Hepatobiliary Pancreat Dis Int. 2003 May;2(2):285-9.
To study the correlation between human cholangiocarcinoma in the porta hepatis and the infection of hepatitis virus.
Immunohistochemistry was used to detect HBxAg and HCV-C protein in formalin-fixed and paraffin-embedded samples taken from 68 patients with cholangiocarcinoma in the porta hepatis. The findings were reviewed against the clinical records of the patients.
Six patients (8.8%) were positive for HBxAg and 24 (35%) for HCV-C protein, respectively. One patient was positive for both HBxAg and HCV-C protein. There were statistically differences in the extent of differentiation, invasion, lymph-node metastasis, and treatment between the patients with cholangiocarcinomas in the porta hepatis with HB(C)V infection and those without infection.
HB(C)V infection is correlated to the development of cholangiocarcinoma in the porta hepatis. The tumor with HB(C)V infection may have a higher malignancy biologically and poorer prognosis. HBxAg and HCV-C protein may play an important role in the pathogenesis of cholangiocarcinoma in the porta hepatis.
研究肝门部胆管癌与肝炎病毒感染之间的相关性。
采用免疫组织化学法检测68例肝门部胆管癌患者福尔马林固定、石蜡包埋标本中的HBxAg和HCV-C蛋白。将检测结果与患者的临床记录进行对照分析。
分别有6例（8.8%）患者HBxAg呈阳性，24例（35%）患者HCV-C蛋白呈阳性。1例患者HBxAg和HCV-C蛋白均呈阳性。肝门部胆管癌伴HB（C）V感染患者与未感染患者在分化程度、浸润、淋巴结转移及治疗方面存在统计学差异。
HB（C）V感染与肝门部胆管癌的发生相关。伴有HB（C）V感染的肿瘤可能具有更高的生物学恶性程度和更差的预后。HBxAg和HCV-C蛋白可能在肝门部胆管癌的发病机制中起重要作用。
