Cui T H
Taicang Rehabilitation Medical Center of Bone Tumors.
Zhonghua Zhong Liu Za Zhi. 1993 Jul;15(4):307-10.
Ninety-three cases of primary malignant bone tumors of the limbs were treated for 651 times with preoperative and postoperative HD-MTX-CFR regimen. A number of toxic side reactions appeared, most of which were those of the digestive tract. The side reactions treated symptomatically subsided uneventfully All cases were followed up for 5-7 years, 36 patients died and 57 survived with a 5-year survival rate of 61.3%. A new method to limb salvage was used in 44 cases: the bone segment with tumor was amputated, and replanted back after inactivation with alcohol excision. The five-year survival rate was 63.6%. The excellent results of treatment gave the patients new hope dispelling the misgivings of becoming disabled.
93例肢体原发性恶性骨肿瘤采用术前、术后大剂量甲氨蝶呤-四氢叶酸解救（HD-MTX-CFR）方案治疗651次。出现了一些毒副反应，其中大部分是消化道反应。对症处理的副反应均顺利消退。所有病例随访5 - 7年，36例死亡，57例存活，5年生存率为61.3%。44例采用了一种新的保肢方法：将肿瘤所在骨段截肢，经酒精灭活切除后再植回。5年生存率为63.6%。良好的治疗效果给患者带来了新希望，消除了他们对致残的疑虑。
