Perevodchikova N I, Eremina L A, Manziuk L V, Siniukov P A, Fedenko A N, Singin A S, Moldovanova L K
Vopr Onkol. 1990;36(6):667-71.
The interim results of the use of high-dose methotrexate with leucovorin rescue for the treatment of 26 patients with osteogenic sarcoma are discussed. Preoperative chemotherapy was followed by marked regression of primary tumor in one out of seven patients with localized disease. In that group, metastasis-free period lasted 2, 3, 10+, 12, 17+ and 24+ months. Response was observed in two out of 19 (10.6%) cases of metastases. Toxic side-effects were moderate and were mainly nausea (38.5% of patients), vomiting (26.9%), elevation of serum transaminase levels (38.5%) and fever (30.7% of cases).
讨论了大剂量甲氨蝶呤联合亚叶酸钙解救治疗26例骨肉瘤患者的中期结果。术前化疗后，7例局限性疾病患者中有1例原发肿瘤明显消退。在该组中，无转移生存期分别为2个月、3个月、超过10个月、12个月、17个月以上和24个月以上。19例转移病例中有2例（10.6%）出现反应。毒副作用为中度，主要是恶心（38.5%的患者）、呕吐（26.9%）、血清转氨酶水平升高（38.5%）和发热（30.7%的病例）。
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