丙酰-L-肉碱对啮齿动物中由刺激物诱导的血浆外渗的抑制作用。

Inhibitory effects of propionyl-L-carnitine on plasma extravasation induced by irritants in rodents.

作者信息

Amico-Roxas M, Caruso A, Cutuli V M, de Bernardis E, Leonardi G

机构信息

Institute of Pharmacology, University of Catania School of Medicine, Italy.

出版信息

Drugs Exp Clin Res. 1993;19(5):213-7.

PMID:8174493

Abstract

The effects of propionyl-L-carnitine (PLC) in various models of inflammation were studied in rats and mice. PLC (50-200 mg/kg i.p.) dose-dependently inhibited the granuloma pouch induced by croton oil in rats, but failed to inhibit either cotton pellet granuloma or carrageenin-induced paw oedema and peritonitis. PLC (100 mg/kg i.p.) significantly reduced mouse ear oedema induced by croton oil, tetradecanoylphorbol acetate and arachidonic acid; in these models, PLC concomitantly reduced plasma extravasation, as evaluated by the leakage of Evans blue. In all the tested models, L-carnitine and acetyl-L-carnitine were ineffective, suggesting a specific protective role of PLC in the vascular component of the inflammatory process.

摘要

在大鼠和小鼠中研究了丙酰-L-肉碱（PLC）在各种炎症模型中的作用。PLC（腹腔注射50-200mg/kg）剂量依赖性地抑制巴豆油诱导的大鼠肉芽肿袋，但未能抑制棉球肉芽肿或角叉菜胶诱导的爪肿胀和腹膜炎。PLC（腹腔注射100mg/kg）显著减轻巴豆油、十四酰佛波醇乙酸酯和花生四烯酸诱导的小鼠耳部水肿；在这些模型中，通过伊文思蓝渗漏评估，PLC同时减少血浆外渗。在所有测试模型中，L-肉碱和乙酰-L-肉碱均无效，表明PLC在炎症过程的血管成分中具有特定的保护作用。