丙酰-L-肉碱对血小板活化因子诱导的大鼠爪肿胀的保护作用。

Protective effect of propionyl-L-carnitine against PAF-induced rat paw oedema.

作者信息

Caruso A, Cutuli V M, De Bernardis E, Leonardi G, Amico-Roxas M

机构信息

Institute of Pharmacology, University of Catania Medical School, Italy.

出版信息

Pharmacol Res. 1995 Jan;31(1):67-72. doi: 10.1016/1043-6618(95)80050-6.

DOI:10.1016/1043-6618(95)80050-6

PMID:7784308

Abstract

Recent reports from our laboratory gave evidence showing that propionyl-L-carnitine (PLC), unlike L-carnitine (LC) and acetyl-L-carnitine (ALC), has anti-inflammatory activity in some models of vascular inflammation in rodents. The present paper shows that PLC (50 to 200 mg kg-1 i.p.) inhibits rat paw oedema induced by platelet activating factor (PAF), while LC and ALC, as well as indomethacin and phenylbutazone, are ineffective. The extent of the maximal inhibition produced by PLC at 200 mg kg-1 was comparable to that of betamethasone 0.05 mg kg-1 or sodium salicylate 100 mg kg-1. PLC inhibited also the early phase (1-2 h) of carrageenin-induced rat paw oedema, which is partly dependent on PAF release, but it was ineffective in the eicosanoid-dependent late phase (3-4 h) of the carrageenin oedema. We suggest that such anti-inflammatory activity of PLC may be due to various mechanisms converging on a stabilizing action upon biomembranes.

摘要

我们实验室最近的报告提供了证据，表明与左旋肉碱（LC）和乙酰左旋肉碱（ALC）不同，丙酰左旋肉碱（PLC）在啮齿动物的某些血管炎症模型中具有抗炎活性。本文表明，PLC（50至200毫克/千克，腹腔注射）可抑制血小板活化因子（PAF）诱导的大鼠足爪水肿，而LC、ALC以及吲哚美辛和保泰松则无效。PLC在200毫克/千克时产生的最大抑制程度与0.05毫克/千克的倍他米松或100毫克/千克的水杨酸钠相当。PLC还抑制了角叉菜胶诱导的大鼠足爪水肿的早期阶段（1至2小时），该阶段部分依赖于PAF的释放，但在角叉菜胶水肿的类花生酸依赖性晚期阶段（3至4小时）无效。我们认为，PLC的这种抗炎活性可能是由于多种机制共同作用于生物膜的稳定作用。