Zhang Li, Hu Juan-Juan, Lin Jian-Wei, Fang Wei-Shuo, Du Guan-Hua
Institute of Materia Medica, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100050, PR China.
J Ethnopharmacol. 2009 Jun 25;123(3):510-4. doi: 10.1016/j.jep.2009.01.039. Epub 2009 Mar 25.
This study evaluates the anti-inflammatory and analgesic activities of the ethanol and aqueous extracts of a Tibetan herb Pterocephalus hookeri (C.B. Clarke) Höeck to provide experimental evidence for its traditional use such as cold, flu and rheumatoid arthritis.
Investigations on the analgesic effects of P. hookeri (C.B. Clarke) Höeck were carried out, including hot-plate test and acetic acid-induced writhing. The anti-inflammatory activities were observed by utilizing the following models: carrageenin-induced edema of the hind paw of rats, cotton pellet-induced granuloma formation in rats, acetic acid-induced permeability, and xylene-induced ear edema in mice. The effects of the administration of indomethacin were also studied.
It has been shown that the ethanol and aqueous extracts significantly increased the hot-plate pain threshold and reduced acetic acid-induced writhing response in mice. The ethanol and aqueous extracts remarkably inhibited the increase in vascular permeability induced by acetic acid and ear edema induced by xylene. The ethanol extract also significantly decreased the carrageenin-induced rat paw edema perimeter and inhibited the increase of granuloma weight.
The results show that the ethanol and aqueous extracts have both central and peripheral analgesic activities and as anti-inflammatory effects, supporting the traditional application of this herb in treating various diseases associated with inflammation and pain.
本研究评估藏药翼首草（Pterocephalus hookeri (C.B. Clarke) Höeck）乙醇提取物和水提取物的抗炎和镇痛活性，为其治疗感冒、流感和类风湿性关节炎等传统用途提供实验依据。
进行了翼首草（Pterocephalus hookeri (C.B. Clarke) Höeck）镇痛作用的研究，包括热板试验和醋酸诱导的扭体反应。通过以下模型观察其抗炎活性：角叉菜胶诱导的大鼠后爪水肿、棉球诱导的大鼠肉芽肿形成、醋酸诱导的通透性以及二甲苯诱导的小鼠耳水肿。还研究了吲哚美辛给药的效果。
结果表明，乙醇提取物和水提取物均能显著提高小鼠热板痛阈值并减少醋酸诱导的扭体反应。乙醇提取物和水提取物均能显著抑制醋酸诱导的血管通透性增加和二甲苯诱导的耳水肿。乙醇提取物还能显著降低角叉菜胶诱导的大鼠爪水肿周长并抑制肉芽肿重量增加。
结果表明，乙醇提取物和水提取物具有中枢和外周镇痛活性以及抗炎作用，支持了该草药在治疗各种炎症和疼痛相关疾病中的传统应用。
