Llobell F, Dávalos R, Laorden M L
Department of Physiology and Pharmacology, School of Medicine, CSV Arrixaca Hospital, Spain.
Eur J Anaesthesiol. 1994 Mar;11(2):123-5.
The present study describes the effects of pimobendan on isolated human right atrial strips and on isolated left atria of the rat. Pimobendan induces a positive inotropic effect both in human and rat preparations. The maximal increase (28 +/- 2.0%) obtained with pimobendan in the strips from human right atria was similar to that obtained in left atria of the rat (31 +/- 1.8%). These observations may have some clinical relevance as pimobendan might prove to be an alternative to catecholamines for inotropic support in patients who undergo general anaesthesia.
本研究描述了匹莫苯丹对离体人右心房条带和大鼠离体左心房的作用。匹莫苯丹在人和大鼠的实验制剂中均诱导出正性肌力作用。匹莫苯丹在人右心房条带中产生的最大增加幅度（28±2.0%）与在大鼠左心房中获得的结果（31±1.8%）相似。这些观察结果可能具有一定的临床相关性，因为对于接受全身麻醉的患者，匹莫苯丹可能被证明是儿茶酚胺用于正性肌力支持的替代药物。
