源自日本野生大鼠（褐家鼠）的新型近交系的建立。

Establishment of new inbred strains derived from Japanese wild rats (Rattus norvegicus).

作者信息

Ohno K, Niwa Y, Kato S, Kondo K, Oda S, Inouye M, Yamamura H

机构信息

Laboratory of Experimental Animals, Yagi Memorial Park, Gifu, Japan.

出版信息

Jikken Dobutsu. 1994 Apr;43(2):251-5. doi: 10.1538/expanim1978.43.2_251.

DOI:10.1538/expanim1978.43.2_251

PMID:8174628

Abstract

Inbreeding of Japanese wild rats (Rattus norvegicus) resulted in five new strains. The conception rates of wild rat strains were lower than those of inbred laboratory strains, and maternal aggressiveness was observed in some wild strains. The body size of domesticated animals was larger than that of captured ancestors. Two strains have been established as inbred strains; the MITA strain has been tamed to the level of laboratory rats, while the nature of the MITD strain is wild. The MITB strain was derived from the MITA strain as a coat color variant. The MITC and MITE strains have been bred to the F15 and F11 generations, respectively. The new strains can provide new genetic variations against a wild type background and might be useful for physiological and psychological experiments.

摘要

日本野生大鼠（褐家鼠）的近亲繁殖产生了五个新的品系。野生大鼠品系的受孕率低于近交系实验大鼠，并且在一些野生品系中观察到母性攻击性。驯化动物的体型比捕获的祖先更大。已将两个品系培育成近交系；米塔（MITA）品系已被驯化成实验大鼠的水平，而米特德（MITD）品系的特性是野生的。米特布（MITB）品系是作为毛色变异体从米塔品系衍生而来的。米特克（MITC）品系和米特伊（MITE）品系分别已繁殖到第15代和第11代。这些新的品系可以在野生型背景下提供新的遗传变异，可能对生理和心理实验有用。