Makin A J, Wendon J, Fitt S, Portmann B C, Williams R
Institute of Liver Studies, King's College Hospital, London.
Gut. 1994 Apr;35(4):569-70. doi: 10.1136/gut.35.4.569.
Hydroxychloroquine is widely used in rheumatological disease but hepatic side effects have not been reported previously. Two cases are described of fulminant hepatic failure developing after the start of hydroxychloroquine treatment for a chronic rheumatological disorder. In both cases the symptoms of liver disease developed within two weeks of starting hydroxychloroquine and rapidly progressed to fulminant hepatic failure and in neither case was there any pre-existing liver disease. One patient had emergency orthotopic liver transplantation and the other died before a donor organ became available.
羟氯喹广泛应用于风湿性疾病，但此前尚未有肝副作用的报道。本文描述了两例在开始使用羟氯喹治疗慢性风湿性疾病后发生暴发性肝衰竭的病例。在这两例中，肝病症状均在开始使用羟氯喹后的两周内出现，并迅速发展为暴发性肝衰竭，且两例均无既往肝病史。其中一名患者接受了紧急原位肝移植，另一名患者在获得供体器官前死亡。
