Zweizig S, Roman L D, Muderspach L I
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles 90033.
Gynecol Oncol. 1994 Apr;53(1):121-2. doi: 10.1006/gyno.1994.1098.
A patient with a history of ovarian carcinoma that had responded well to cisplatin was treated with platinum agents for a recurrence. She had a seizure while receiving carboplatin and was switched to cisplatin. The patient was premedicated with antihistamines and steroids. After approximately 400 micrograms of cisplatin she went into anaphylactic shock and could not be resuscitated. The reported frequency of hypersensitivity reactions to cisplatin is between 1 and 20%. Premedication with steroids and antihistamines, single-agent chemotherapy, and slow rate of infusion are of help in preventing these reactions. All of these precautions were unsuccessful in preventing refractory anaphylaxis in this patient.
一名有卵巢癌病史且对顺铂反应良好的患者因复发接受铂类药物治疗。她在接受卡铂治疗时发生癫痫，随后改用顺铂。患者预先使用了抗组胺药和类固醇进行预处理。在输注约400微克顺铂后，她发生过敏性休克，未能复苏。据报道，对顺铂过敏反应的发生率在1%至20%之间。使用类固醇和抗组胺药进行预处理、单药化疗以及缓慢输注速度有助于预防这些反应。所有这些预防措施均未能成功预防该患者的难治性过敏反应。
