Zhou X J, Yu A W, Zhou F Q, Ryu J, Ing T S, Vaziri N D
Department of Medicine, University of California at Irvine.
Int J Artif Organs. 1993 Dec;16(12):816-9.
An exposure of human neutrophils to an acidic (pH 5.2), lactate-based incubation mixture containing a conventional, acidic, lactate-based peritoneal dialysis solution (PDS) resulted in the development of a prompt and substantial intracellular acidosis. A comparable exposure to a euhydric, bicarbonate-based incubation mixture containing a euhydric, bicarbonate-based PDS did not bring about similar changes in intracellular pH. The absence of an intracellular acidosis in the instance of the euhydric, bicarbonate-based PDS may be the reason why this solution is more biocompatible than its acidic, lactate-based counterpart.
将人类中性粒细胞暴露于含有传统酸性乳酸盐腹膜透析液（PDS）的酸性（pH 5.2）乳酸盐孵育混合物中，会迅速导致细胞内出现明显酸中毒。而将其暴露于含有等渗碳酸氢盐PDS的等渗碳酸氢盐孵育混合物中，细胞内pH值则不会发生类似变化。等渗碳酸氢盐PDS不会导致细胞内酸中毒，这可能是该溶液比酸性乳酸盐对应溶液具有更高生物相容性的原因。
