Gewiese B, Beuthan J, Fobbe F, Stiller D, Müller G, Böse-Landgraf J, Wolf K J, Deimling M
Department of Radiology, Klinikum Steglitz, Berlin, Germany.
Invest Radiol. 1994 Mar;29(3):345-51. doi: 10.1097/00004424-199403000-00015.
Laser-induced interstitial thermotherapy (LITT) may become an attractive modality for minimally invasive tumor therapy. Magnetic resonance imaging (MRI) could be used to assist this procedure.
A T1-weighted turbo fast low-angle shot (FLASH) sequence for on-line monitoring of the laser-influenced region (liver, muscle) was investigated. Sequence parameters were optimized for maximal image contrast. Magnetic resonance imaging-controlled LITT was performed in vitro, in vivo (rabbits), and in 8 human investigations (6 patients). Special laser applicators were used to establish a uniform laser light distribution.
With the MRI sequence used, the LITT region is visualized as a bright area outlined by a dark border. This dark border corresponds to an isotherm of 45 +/- 2 degrees C depending on the sequence parameters used.
With the T1-weighted turbo-FLASH sequence, MRI can be used for on-line monitoring of interstitial laser-induced thermotherapy in moving organs.
激光诱导间质热疗（LITT）可能成为一种有吸引力的微创肿瘤治疗方式。磁共振成像（MRI）可用于辅助该手术。
研究了一种用于在线监测激光影响区域（肝脏、肌肉）的T1加权快速低角度激发（FLASH）序列。对序列参数进行了优化以获得最大图像对比度。在体外、体内（兔子）以及8例人体研究（6名患者）中进行了磁共振成像控制的LITT。使用特殊的激光施照器来建立均匀的激光分布。
使用所采用的MRI序列，LITT区域显示为一个由暗边界勾勒出的明亮区域。根据所使用的序列参数，这个暗边界对应于45±2摄氏度的等温线。
利用T1加权快速FLASH序列，MRI可用于对运动器官中间质激光诱导热疗进行在线监测。
