Bremer C, Allkemper T, Menzel J, Sulkowski U, Rummeny E, Reimer P
Institute for Clinical Radiology, Westfaelische Wilhelms University, Meunster, Germany.
J Magn Reson Imaging. 1998 Jan-Feb;8(1):235-9. doi: 10.1002/jmri.1880080139.
The purpose of this preliminary study was to evaluate whether laser-induced interstitial thermotherapy (LITT) may be used for palliative treatment of localized hepatocellular carcinomas (HCC). We applied LITT to two patients suffering from unresectable localized hepatocellular carcinomas of different sizes (2.5 and 4 cm). LITT was performed with an Nd:YAG laser (1,064 nm) at 5 W laser power (15-20 minutes). Thermometry during LITT was performed by MRI using a temperature-sensitive T1-weighted fast low-angle shot (FLASH) sequence. Follow-up for local tumor control was performed by MRI and ultrasound. LITT was well tolerated and no adverse events occurred during or after LITT; no secondary liver lesions were seen in the follow-up (11 or 12 months, respectively). Only minimal tumor growth was observed in the larger HCC (from 4 to 5 cm), whereas the smaller HCC remained unchanged in size during 11 months of follow-up. We conclude that LITT might be an effective minimally invasive palliative treatment option for patients with small unresectable HCC.
这项初步研究的目的是评估激光诱导间质热疗（LITT）是否可用于局部肝细胞癌（HCC）的姑息治疗。我们对两名患有不同大小（2.5厘米和4厘米）不可切除的局部肝细胞癌患者应用了LITT。使用Nd:YAG激光（1064纳米）以5瓦激光功率进行LITT（15 - 20分钟）。LITT期间的温度测量通过MRI使用温度敏感的T1加权快速低角度激发（FLASH）序列进行。通过MRI和超声对局部肿瘤控制进行随访。LITT耐受性良好，LITT期间或之后未发生不良事件；随访期间（分别为11或12个月）未发现继发性肝脏病变。在较大的HCC中仅观察到最小程度的肿瘤生长（从4厘米至5厘米），而较小的HCC在11个月的随访期间大小保持不变。我们得出结论，LITT可能是小的不可切除HCC患者的一种有效的微创姑息治疗选择。
