抗生素GE37468 A：一种新型细菌蛋白质合成抑制剂。II. 结构解析。
Antibiotic GE37468 A: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation.
作者信息
Ferrari P, Colombo L, Stella S, Selva E, Zerilli L F
机构信息
Marion Merrell Dow Research Institute, Lepetit Research Center, Gerenzano (VA), Italy.
出版信息
J Antibiot (Tokyo). 1995 Nov;48(11):1304-11. doi: 10.7164/antibiotics.48.1304.
GE37468 A is a novel antibiotic produced by Streptomyces sp. ATCC 55365. It has molecular mass 1309.48 and formula C59H52O12N14S5 and belongs to the thiazolyl peptide group of antibiotics. The structure was elucidated by 1H and 13C NMR and MS studies on intact molecule and its hydrolysis products. The antibiotic is a highly modified peptide containing a macrocycle and a side chain composed of a thiazole ring and two dehydroalanine units.
GE37468 A是由链霉菌属ATCC 55365产生的一种新型抗生素。它的分子量为1309.48，分子式为C59H52O12N14S5，属于噻唑基肽类抗生素。通过对完整分子及其水解产物进行1H和13C核磁共振以及质谱研究，阐明了其结构。该抗生素是一种高度修饰的肽，含有一个大环和一个由噻唑环和两个脱氢丙氨酸单元组成的侧链。
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