Nishi T, Higashi K, Soga T, Takemura M, Sato M
Exploratory Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
J Antibiot (Tokyo). 1994 Mar;47(3):357-69. doi: 10.7164/antibiotics.47.357.
A series of new penems (4-17), having a bicyclic imidazole moiety as the C-2 substituent, has been synthesized. The antimicrobial activity of these compounds and their susceptibility to renal dehydropeptidase-1 (DHP-1) are elucidated, and their structure-activity relationships are discussed.
已经合成了一系列以双环咪唑部分作为C-2取代基的新型青霉烯（4-17）。阐明了这些化合物的抗菌活性及其对肾脱氢肽酶-1（DHP-1）的敏感性，并讨论了它们的构效关系。
