Taylor C R, Flotte T J, Gange R W, Anderson R R
Department of Dermatology, Harvard Medical School, Boston, MA.
J Am Acad Dermatol. 1994 May;30(5 Pt 1):743-51. doi: 10.1016/s0190-9622(08)81505-8.
There are few reports on therapy for nevus of Ota. Moreover, traditional treatments are largely palliative or risk permanent pigmentary changes and/or scarring.
The efficacy of the Q-switched ruby laser (694 nm, 40 nsec) as a therapy for nevus of Ota was investigated.
Nine nevi or portions thereof were irradiated up to six times with 4.5 and/or 7.5 J/cm2 at a mean exposure interval of 3 weeks. Sequential skin biopsy specimens were processed for light microscopy, immunohistochemistry, and electron microscopy.
Cosmetic improvement occurred at both doses in the irradiated parts of the six nevi available for follow-up. No appreciable difference was noted between single and multiple treatments. There was no gross scarring. Light microscopy revealed dose-related immediate injury with more melanophages and fewer dermal melanocytes after irradiation in comparison with control areas. Electron microscopic distinction between dermal melanocytes and melanin-laden macrophages was difficult. A monoclonal antibody to human melanosome-specific antigen type 1 (HMSA-1) was used to distinguish between the two cell populations.
Our findings suggest that the Q-switched ruby laser is useful for treating nevus of Ota.
关于太田痣治疗的报道较少。此外，传统治疗大多只是姑息性的，且有导致永久性色素改变和/或瘢痕形成的风险。
研究调Q红宝石激光（694nm，40纳秒）治疗太田痣的疗效。
对9个太田痣或其部分区域以4.5和/或7.5J/cm²的能量照射多达6次，平均照射间隔为3周。对连续获取的皮肤活检标本进行光学显微镜检查、免疫组织化学检查和电子显微镜检查。
在可进行随访的6个太田痣的照射部位，两种剂量均出现了美容改善。单次治疗和多次治疗之间未发现明显差异。未出现明显瘢痕。光学显微镜检查显示，与对照区域相比，照射后存在剂量相关的即刻损伤，黑色素吞噬细胞增多，真皮黑素细胞减少。通过电子显微镜难以区分真皮黑素细胞和载黑素巨噬细胞。使用针对人黑素小体特异性抗原1型（HMSA-1）的单克隆抗体来区分这两种细胞群。
我们的研究结果表明，调Q红宝石激光可用于治疗太田痣。
