Faulkner R T, Czajkowski W P, Rayfield E J, Hickman R L
Am J Vet Res. 1976 Apr;37(4):473-5.
A technique was developed for catheterization of the portal vein in rhesus monkeys (Macaca mulatta). Silicone rubber catheters (0.040 ID by 0.085 inch OD, or 0.030 ID by 0.065 inch OD) were surgically placed into the portal vein via the umbilical, inferior mesenteric, right colic, or ileocolic veins. The right colic and ileocolic veins proved to be the preferred route for catheterization. Both single end-hole and multiple end-hole catheters with 2 side holes were used. Catheter function was dependent upon proper placement within the portal vein and on maintaining patency. Single-hole catheters were successfully maintained by periodic flushing (2-3 times daily) with heparinized saline solution (1.5-4.0 units/ml), and multiple-hole catheters were best maintained by a continuous flow (1-2 ml/hour) of heparinized saline solution (1.5 units/ml). No adverse clinical effects due to the portal catheter were observed in any of the monkeys catheterized. The technique allowed placing the monkey in a restraint chair, thus enabling one to utilize the monkey in a conscious state.
已开发出一种用于恒河猴（猕猴）门静脉插管的技术。通过脐静脉、肠系膜下静脉、右结肠静脉或回结肠静脉，将硅橡胶导管（内径0.040英寸，外径0.085英寸，或内径0.030英寸，外径0.065英寸）手术置入门静脉。结果证明，右结肠静脉和回结肠静脉是插管的首选途径。使用了单端孔导管和带有2个侧孔的多端孔导管。导管功能取决于在门静脉内的正确放置以及保持通畅。单孔导管通过每天用肝素化盐水溶液（1.5 - 4.0单位/毫升）定期冲洗（每日2 - 3次）成功维持通畅，多孔导管通过肝素化盐水溶液（1.5单位/毫升）以1 - 2毫升/小时的连续流速维持效果最佳。在任何接受插管的猴子中均未观察到因门静脉导管导致的不良临床效应。该技术可将猴子置于约束椅中，从而能够在清醒状态下使用猴子。
