Soga T, Shirai A, Igarashi T, Kato K, Ishigatsubo Y, Okubo T
Department of Medical Informatics, School of Medicine, Yokohama City University.
Kansenshogaku Zasshi. 1994 Mar;68(3):411-5. doi: 10.11150/kansenshogakuzasshi1970.68.411.
We report a case of Listeria meningitis associated with systemic lupus erythematosus (SLE). The case is a 29-year-old female who was diagnosed as SLE on August, 1982, and had been followed since then. On May 25, 1993, she was admitted to our hospital with complaints of fever, head ache and vomiting which developed 3 days before admission. An examination of the cerebro-spinal fluid (CSF) revealed a cell count of (3664/3/mm3), protein concentration (123 mg/dl), and the quotient of CSF (Q albumin) (27.5) were elevated. A diagnosis of meningitis was made and therapy of antibiotics was begun. A CSF culture on admission was positive for Listeria monocytogenes, but the blood culture was negative. Clinical symptoms disappeared in about a week and abnormal CSF findings returned to normal in about a month with the administration of antibiotics. Listeria infection is a rare disease, but sometimes develops as an opportunistic infection in immunocompromised hosts. As far as we know, only 13 cases have been reported so far (9 cases in foreign countries, 4 cases in Japan). We also discuss Listeria infections associsted with SLE referring to the former reports.
我们报告一例与系统性红斑狼疮（SLE）相关的李斯特菌性脑膜炎病例。该病例为一名29岁女性，于1982年8月被诊断为SLE，此后一直接受随访。1993年5月25日，她因入院前3天出现发热、头痛和呕吐症状入住我院。脑脊液（CSF）检查显示细胞计数为（3664/3/mm³），蛋白浓度（123mg/dl），脑脊液商值（Q白蛋白）（27.5）升高。诊断为脑膜炎并开始使用抗生素治疗。入院时脑脊液培养单核细胞增生李斯特菌呈阳性，但血培养为阴性。使用抗生素治疗后，临床症状在约一周内消失，脑脊液异常结果在约一个月内恢复正常。李斯特菌感染是一种罕见疾病，但有时会在免疫功能低下的宿主中作为机会性感染发生。据我们所知，迄今为止仅报告了13例（国外9例，日本4例）。我们还参考以前的报告讨论了与SLE相关的李斯特菌感染。
