Horta-Baas Gabriel, Guerrero-Soto Omar, Barile-Fabris Leonor
Servicio de Reumatología, Hospital General Regional 220, Instituto Mexicano del Seguro Social, Toluca de Lerdo, Estado de México, México.
Reumatol Clin. 2013 Nov-Dec;9(6):340-7. doi: 10.1016/j.reuma.2013.04.011. Epub 2013 Oct 2.
Infections in patients with systemic lupus erythematosus cause significant morbidity. Infection due to Listeria monocytogenes (LM) is considered an opportunistic disease, and has been published on rare occasions in patients with SLE.
To review the presentation of listeria infections in the central nervous system (CNS) in SLE patients.
We conducted a literature review, selecting cases with central nervous system infection and confirmation of LM infection through culture.
Twenty six cases are described. The most common presentation was meningitis, with meningoencephalitis and brain abscesses being less frequent. The predisposing factors are: use of glucocorticoids, immunosuppressants, renal replacement therapy and the activity flares.
CNS infection by listeria is rare and sometimes fatal. The atypical presentation may lead to a delay in diagnosis and appropriate treatment. L. monocytogenes should be included in the differential diagnosis of patients with SLE with neurological manifestations.
系统性红斑狼疮患者发生感染会导致显著的发病率。单核细胞增生李斯特菌（LM）感染被认为是一种机会性疾病，在系统性红斑狼疮患者中鲜有报道。
回顾系统性红斑狼疮患者中枢神经系统（CNS）李斯特菌感染的表现。
我们进行了一项文献综述，选择中枢神经系统感染且经培养确诊为LM感染的病例。
共描述了26例病例。最常见的表现是脑膜炎，脑膜脑炎和脑脓肿较少见。诱发因素包括：使用糖皮质激素、免疫抑制剂、肾脏替代治疗以及病情活动发作。
李斯特菌引起的中枢神经系统感染罕见，有时会致命。非典型表现可能导致诊断和适当治疗的延迟。单核细胞增生李斯特菌应纳入有神经表现的系统性红斑狼疮患者的鉴别诊断中。
