Doster B, Caras G J, Snider D E
Am Rev Respir Dis. 1976 Apr;113(4):419-25. doi: 10.1164/arrd.1976.113.4.419.
From 1961 through 1968 the incidence of primary drug resistance was monitored among patients admitted to 22 participating hospitals. The patients were believed to have newly diagnosed, previously untreated, bacteriologically proved pulmonary tuberculosis. During the study period the level of primary resistance to isoniazid, streptomycin, and para-aminosalicylic acid remained very low; there was no indication that primary resistance to these drugs was increasing. Investigation of patient histories revealed that a significant proportion of persons initially believed to have been previously untreated actually had received prior chemotherapy. Resistance rates to both isoniazid and streptomycin were significantly higher among younger patients than among older patients. No relationship was found between race or sex and primary resistance rates. The low incidence of drug resistance found in this survey suggests that disease caused by virulent resistant organisms occurs infrequently.
1961年至1968年期间，对22家参与研究的医院收治的患者进行了原发性耐药性监测。这些患者被认为是新诊断出的、此前未接受过治疗且经细菌学证实的肺结核患者。在研究期间，对异烟肼、链霉素和对氨基水杨酸的原发性耐药水平一直很低；没有迹象表明对这些药物的原发性耐药性在增加。对患者病史的调查显示，很大一部分最初被认为此前未接受过治疗的人实际上曾接受过先前的化疗。年轻患者中异烟肼和链霉素的耐药率显著高于老年患者。未发现种族或性别与原发性耐药率之间存在关联。本次调查中发现的低耐药发生率表明，由强毒耐药菌引起的疾病很少发生。
