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用于中耳功能临床问题研究的灵长类动物模型。

Primate model for studies of clinical problems of middle ear functions.

作者信息

Miller J, Donaldson J

出版信息

Ann Otol Rhinol Laryngol. 1976 Mar-Apr;85(2 Suppl 25 Pt 2):194-201. doi: 10.1177/00034894760850S237.

DOI:10.1177/00034894760850S237
PMID:817637
Abstract

Eustachian tube and middle ear function has been studied in the acute and chronically prepared Rhesus monkey preparation. Measures have included observations of tympanometry and input impedance of the middle ear, of transmission of energy through the middle ear, of static middle ear pressure and of threshold and suprathreshold hearing. Positive and negative long and short-term static middle ear pressures, the effects of middle ear fluids, and various aspects of Eustachian tube function in both normal and pathologic preparations have been studied. In general our observations indicate that the Old World monkey may provide a model permitting acquisition of quantitative data of a variety of middle ear functions under carefully controlled laboratory conditions, including those requiring measures simply not possible in man.

摘要

咽鼓管和中耳功能已在急性和慢性制备的恒河猴模型中进行了研究。测量方法包括观察中耳的鼓室导抗图和输入阻抗、中耳能量传递、中耳静态压力以及阈值和阈上听力。研究了正常和病理状态下中耳的正负长期和短期静态压力、中耳积液的影响以及咽鼓管功能的各个方面。总体而言,我们的观察表明,旧世界猴可能提供一个模型,允许在精心控制的实验室条件下获取各种中耳功能的定量数据,包括那些在人类中根本无法进行测量的情况。

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Primate model for studies of clinical problems of middle ear functions.用于中耳功能临床问题研究的灵长类动物模型。
Ann Otol Rhinol Laryngol. 1976 Mar-Apr;85(2 Suppl 25 Pt 2):194-201. doi: 10.1177/00034894760850S237.
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