Timoshko M A, Moskalik R S, Nikolaeva A V, Minaeva K N, Shirshova A I
Antibiotiki. 1975 Nov;20(11):1024-7.
Levomycetin effect on the microflora introduced into the intestine of abiotic chickens was studied. Levomycetin in a dose of 4 mg perosone chicken for 5 days provided a decrease in the number of Bifidobacteria, Lactobacteria, Escherichia and Enterococci by 100 to 10000 times and an increase in the number of Candida or disbacteriosis in the intestine. The highest effect was observed with respect to multiplication of Lactobacteria. This impaired the ecological quantitative ratio between the microorganisms. Re-establishment of the microbial biocenosis after discontinuation of levomycetin use was not complete. Repeated disbacteriosis in the gastrointestinal tract of the test-chickens was registered on the 16th day.
研究了氯霉素对引入无菌鸡肠道内微生物区系的影响。以每只鸡口服4毫克氯霉素，连续5天，结果双歧杆菌、乳酸菌、大肠杆菌和肠球菌数量减少了100至10000倍，念珠菌数量增加，肠道出现菌群失调。观察到对乳酸菌增殖的影响最为显著。这破坏了微生物之间的生态定量比例。停用氯霉素后微生物生物群落的重建并不完全。在第16天检测到试验鸡胃肠道再次出现菌群失调。
