Furey P C, Macgillivray D C, Castiglione C L, Allen L
Department of Surgery, University of Connecticut School of Medicine, Farmington 06032.
J Surg Oncol. 1994 Mar;55(3):194-7. doi: 10.1002/jso.2930550313.
A retrospective study was done to evaluate the frequency and severity of wound complications in 112 patients with breast cancer who received adjuvant chemotherapy following mastectomy with immediate breast reconstruction. Data on wound complications were available for 120 mastectomies. The rate of complications in 36 mastectomies treated with chemotherapy after mastectomy and immediate reconstruction was compared to that in 84 mastectomies not receiving adjuvant therapy. There were 25 wound complications (20.8%) in the entire group. The rate of wound complications was 27.8% (10 of 36 mastectomies) in the group treated with adjuvant chemotherapy and 17.9% (15 of 84 mastectomies) in the group that did not receive adjuvant therapy (P = 0.13). No patient had a delay in the initiation of adjuvant therapy because of wound complications secondary to immediate reconstruction. Logistic regression analysis found no correlation between age, type of operation, tumor pathology, stage, number of lymph nodes harvested, type of prosthesis or chemotherapy, and wound complications in patients undergoing immediate breast reconstruction after mastectomy. The frequency of wound complications was not increased in patients receiving adjuvant chemotherapy after mastectomy and immediate breast reconstruction. The administration of adjuvant chemotherapy does not need to be delayed in patients who have had immediate breast reconstruction following mastectomy for breast cancer.
进行了一项回顾性研究，以评估112例乳腺癌患者在乳房切除术后立即进行乳房重建并接受辅助化疗时伤口并发症的发生率和严重程度。有120例乳房切除术的伤口并发症数据。将36例乳房切除术后立即重建并接受化疗的伤口并发症发生率与84例未接受辅助治疗的乳房切除术的发生率进行比较。整个组中有25例伤口并发症（20.8%）。辅助化疗组的伤口并发症发生率为27.8%（36例乳房切除术中10例），未接受辅助治疗组为17.9%（84例乳房切除术中15例）（P = 0.13）。没有患者因即刻重建继发的伤口并发症而延迟辅助治疗的开始。逻辑回归分析发现，年龄、手术类型、肿瘤病理、分期、切除的淋巴结数量、假体类型或化疗与乳房切除术后即刻乳房重建患者的伤口并发症之间无相关性。乳房切除术后立即进行乳房重建并接受辅助化疗的患者伤口并发症的发生率没有增加。对于乳腺癌乳房切除术后立即进行乳房重建的患者，无需延迟辅助化疗的给药。
