毛喉素在体外并不会增强犬类内脏多模式感受器对缓激肽的反应。

Forskolin does not augment the bradykinin response of canine visceral polymodal receptors in vitro.

作者信息

Mizumura K, Minagawa M, Koda H, Kumazawa T

机构信息

Department of Neural Regulation, Nagoya University, Japan.

出版信息

Neurosci Lett. 1994 Jan 31;166(2):195-8. doi: 10.1016/0304-3940(94)90484-7.

DOI:10.1016/0304-3940(94)90484-7

PMID:8177499

Abstract

In clarifying the possible involvement of cyclic AMP (cAMP) in prostaglandin (PG) E2-induced sensitization of the bradykinin response of canine testicular polymodal receptors, the effects of forskolin, an activator of adenylyl cyclase, were studied in the presence and absence of acetylsalicylic acid (ASA, 550 microM) which blocks PG production. Forskolin (10 microM) seldom induced discharges in polymodal receptors. An unexpected outcome of this study was that forskolin induced no facilitation of the bradykinin (0.1 microM) response, both in the absence and presence of ASA. A slight yet significant suppression of the bradykinin response was instead observed in the absence of ASA. These results suggest that intracellular cAMP may be related with PG E2-induced sensitization of the bradykinin response through its decrease.

摘要

在阐明环磷酸腺苷（cAMP）可能参与前列腺素（PG）E2诱导的犬睾丸多模式感受器缓激肽反应致敏过程中，研究了腺苷酸环化酶激活剂福斯高林在存在和不存在乙酰水杨酸（ASA，550微摩尔）情况下的作用，乙酰水杨酸可阻断PG生成。福斯高林（10微摩尔）很少诱导多模式感受器放电。本研究一个意外的结果是，无论有无ASA，福斯高林均未诱导缓激肽（0.1微摩尔）反应的易化。相反，在不存在ASA的情况下，观察到缓激肽反应有轻微但显著的抑制。这些结果表明，细胞内cAMP可能通过其减少与PG E2诱导的缓激肽反应致敏有关。