Bier H, Haas I, Koldowski P
Department of Otorhinolaryngology, Heinrich Heine University, Düsseldorf, FRG.
ORL J Otorhinolaryngol Relat Spec. 1994 Mar-Apr;56(2):96-100. doi: 10.1159/000276618.
Strain 2 guinea pigs bearing the transplanted intradermally growing line 10 tumor underwent surgical excision of the primary lesion at a time when the tumor had already metastasized to the first draining lymph node. Postoperative perilymphatic immunotherapy with 500 or 5,000 IU of interleukin-2 (IL-2) for 12 consecutive days failed to cure the animals of residual lymphatic micrometastasis. Similarly, intratumoral IL-2 treatment of nonoperated guinea pigs did not alter the natural course of the disease. However, histological serial examination of the tumor-draining lymph nodes at the end of immunotherapy revealed significantly less tumor occupation in all IL-2-treated animals as compared to control animals.
携带经皮内移植生长的10号线瘤的2号品系豚鼠，在肿瘤已转移至首个引流淋巴结时，对原发性病变进行了手术切除。术后连续12天用500或5000国际单位的白细胞介素-2（IL-2）进行淋巴管周围免疫治疗，未能治愈动物的残留淋巴管微转移。同样，对未手术的豚鼠进行瘤内IL-2治疗也未改变疾病的自然进程。然而，免疫治疗结束时对肿瘤引流淋巴结的组织学连续检查显示，与对照动物相比，所有接受IL-2治疗的动物中肿瘤占据明显减少。
