Bier H, Armonat G, Bier J, Schirrmacher V, Ganzer U
Department of Otorhinolaryngology, Klinikum Mannheim, FRG.
ORL J Otorhinolaryngol Relat Spec. 1989;51(4):197-205. doi: 10.1159/000276059.
Strain 2 guinea pigs bearing the transplanted intradermally growing line 10 tumor underwent surgical tumor excision at a time when the tumor had already metastasized to the first draining lymph node. Postoperative active-specific immunotherapy (ASI) consisted of two vaccinations with either Newcastle disease virus (NDV) modified or BCG-admixed line 10 tumor cells. 32% of the animals were cured of residual lymphatic micrometastasis by ASI with NDV-modified tumor cells while ASI with BCG was successful in 45%. No synergistic effect was observed when both ASI procedures were combined. Vaccine preparations with mitomycin C inactivated tumor cells proved to be less (NDV) or noneffective (BCG) compared to those with irradiated tumor cells.
携带移植的皮内生长的10号线瘤的2号豚鼠，在肿瘤已经转移至首个引流淋巴结时接受了肿瘤手术切除。术后主动特异性免疫疗法（ASI）包括用新城疫病毒（NDV）修饰的或卡介苗混合的10号线瘤细胞进行两次接种。32%的动物通过用NDV修饰的肿瘤细胞进行的ASI治愈了残留的淋巴微转移，而用卡介苗进行的ASI成功率为45%。当两种ASI程序联合使用时未观察到协同效应。与用辐照肿瘤细胞的疫苗制剂相比，用丝裂霉素C灭活肿瘤细胞的疫苗制剂效果较差（NDV）或无效（卡介苗）。
