Zieliński K W, Kulig A
Department of Pathomorphology, Military University School of Medicine, Lódź.
Pol J Pathol. 1994;45(1):17-28.
Comparative results of morphometric investigations describing the microvasculature of the human left ventricle heart wall muscle have been presented. The control group consisted of 11 autopsied cases of the atherosclerotically non damaged hearts and the second group consisted of 13 autopsied cases of the hearts with double or triple vessel chronic coronary atherosclerosis. The age of subjects ranged from 47 to 85 (median 65). The study was carried out on microscopical slides using digital image analyser. In the control group a significantly lower number and profile area of capillaries was noticed in the subendocardial zone than in the remaining ones. The differences between control and atherosclerotic hearts were most prominent in the subendocardial zone, although they were observed in the subepicardial and intramyocardial zones as well. If the value of each parameter in the subendocardial zone of the control hearts will be fixed equally to 100%, the corresponding values in atherosclerotic group are: the number of capillaries--34%, total area of capillaries--65%, number of collaterals--170%, total area of collaterals--612%, muscle fibre/capillary ratio--137%, the degree of microvasculature anisotropy--164%. On the ground of this study as well as on the qualitative investigations it is postulated that the chronic atherosclerosis of extra-myocardial coronary arteries corresponds to intramyocardial rebuilding of the capillary network worsen the conditions of muscle fibre nutrition.
本文展示了描述人类左心室心肌壁微血管系统的形态学研究的对比结果。对照组由11例无动脉粥样硬化损伤的心脏尸检病例组成，第二组由13例患有双支或三支血管慢性冠状动脉粥样硬化的心脏尸检病例组成。受试者年龄在47至85岁之间（中位数为65岁）。该研究使用数字图像分析仪在显微镜载玻片上进行。在对照组中，心内膜下区域的毛细血管数量和轮廓面积明显低于其他区域。对照组与动脉粥样硬化心脏之间的差异在心内膜下区域最为显著，尽管在心外膜下和心肌内区域也有观察到。如果将对照组心脏心内膜下区域各参数的值均设定为100%，则动脉粥样硬化组的相应值为：毛细血管数量——34%，毛细血管总面积——65%，侧支数量——170%，侧支总面积——612%，肌纤维/毛细血管比率——137%，微血管各向异性程度——164%。基于本研究以及定性研究，推测心肌外冠状动脉的慢性动脉粥样硬化与心肌内毛细血管网络的重建相对应，这会恶化肌纤维营养状况。
