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[不同品系小鼠肝脏再生过程中淋巴组织反应性的遗传差异]

[Genetic differences in lymphoid tissue reactivity during liver regeneration in mice of different lines].

作者信息

Babaeva A G, Iudina N V, Gambarov S S

出版信息

Biull Eksp Biol Med. 1976 Jul;82(7):876-8.

PMID:8178
Abstract

The transfer of lymphocytes together with sheep erythrocytes from partially hepatectomized mice to syngenous lethally irradiated mice (CAB and C57BL) increased the number of antibody forming cells in the recipient's spleen. The lymphocytes of CBA mice acquired this ability much earlier after the operation (in 4 hours) than those of the C57BL mice (in 17 hours). After the transfer of lymphocytes in the semisyngenous system there was a decrease of antibody forming cells during subsequent recipient's immunization with sheep erythrocytes; this was the result of the graft versus host reaction. The latter reaction was less marked in the operated than in control mice. These changes also occurred earlier after the operation in the CBA than in C57BL mice.

摘要

将部分肝切除小鼠的淋巴细胞与绵羊红细胞一起转移至同基因致死性照射小鼠(CAB和C57BL)体内,可增加受体脾脏中抗体形成细胞的数量。CBA小鼠的淋巴细胞在术后更早(4小时)获得这种能力,而C57BL小鼠的淋巴细胞则在17小时后获得。在半同基因系统中转移淋巴细胞后,在随后用绵羊红细胞对受体进行免疫期间,抗体形成细胞数量减少;这是移植物抗宿主反应的结果。与对照小鼠相比,手术小鼠中的后一种反应不太明显。这些变化在CBA小鼠中也比C57BL小鼠术后更早出现。

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